When it comes to care, the American Wirehair’s coat does require a bit of brushing and combing although too much could result in damaging their fur. The best time to comb their coats is when cats start shedding in the spring. If you buy or adopt a young American Wirehair, you should try to teach them to let you brush their teeth because it’s the best way of reducing the risk of periodontal disease developing. It is also a very good idea to check their ears on a regular basis to make sure there are not mites or infections. As with all cats, American Wirehairs really don’t like using a litter tray if it is dirty or smelly and may well refuse to use one if it is placed too closed to their food or water bowls. Regular visits to the vet are a must for health checks and to keep up with annual vaccinations.